Introduction to the HPV Vaccines Work Group
Oliver Brooks, MD
Chair, HPV Vaccine Work Group
Advisory Committee on Immunization Practices
June 28, 2024
National Center for Immunization & Respiratory Diseases
2006
2011
2016 2019
Recommendation for Females
Routine: 11 or 12 years,
can be started at age 9
Catch-up: through 26 years
3-dose schedule
Evolution of HPV vaccination recommendations –
United States
2
Recommendation for Males
Routine: 11 or 12 years,
can be started at age 9
Catch-up: through 21 years
3-dose schedule
2-dose schedule
if first dose
age <15 years
Catch-up: through 26
Shared clinical decision-
making: some adults
27 through 45 years
2006
2011
2016 2019
Recommendation for Females
Routine: 11 or 12 years,
can be started at age 9
Catch-up: through 26 years
3-dose schedule
Evolution of HPV vaccination recommendations –
United States
3
Recommendation for Males
Routine: 11 or 12 years,
can be started at age 9
Catch-up: through 21 years
3-dose schedule
2-dose schedule
if first dose
age <15 years
Catch-up: through 26
Shared clinical decision-
making: some adults
27 through 45 years
Quadrivalent Vaccine
Bivalent Vaccine
Vaccines
available
9-valent Vaccine
• Routine vaccination
- Age 11 or 12 years
- Can be started at age 9 years
• Catch-up vaccination
- Through age 26 years
• Shared clinical decision-making
- Age 27–45 years
Current HPV vaccination recommendations,
United States
Recommendations of the Centers for Disease Control and Prevention and the Advisory Committee on Immunization Practices
https://www.cdc.gov/vaccines/hcp/acip-recs/vacc-specific/hpv.html
Number of doses
2 doses (0, 6-12 months)
if starting series before 15
th
birthday
3 doses (0,1-2, 6 months)
if starting series on or after 15
th
birthday or if
immunocompromising condition
4
• Number of doses in the recommended HPV vaccination series
• Wording of the age for routine vaccination
• Guidance regarding persons in the “shared clinical decision-making” age
range (27–45 years)
Topics to be considered by HPV Vaccines Work Group
5
• Number of doses in the recommended HPV vaccination series
- Accumulating evidence on efficacy of HPV vaccination with fewer doses
- In 2022, the World Health Organization recommended a two-dose schedule for
persons aged 9 years or older and, as an off-label option, a single-dose schedule
can be used for those aged 9–20 years
Topics to be considered by HPV Vaccines Work Group
6
• Wording of the age for routine HPV vaccination
- Some stakeholders interested in starting vaccination at age 9 years
- Current ACIP recommendations are consistent with vaccination at age 9 years
- Modification of wording could allow more flexibility
Topics to be considered by HPV Vaccines Work Group
7
• Guidance regarding persons in the “shared clinical decision-making” age
range (27–45 years)
- Shared clinical decision-making recommendation made in 2019
- Interest in providing more guidance for subgroups in this age range
Topics to be considered by HPV Vaccines Work Group
8
• July 2024 – first meeting of Work Group
• October 2024 – presentation of general issues to full ACIP
- Number of doses in the HPV vaccination schedule
- Routine age recommendation wording
ACIP HPV Vaccines Work Group initial timeline
9
ACIP HPV Vaccines Work Group
Chair
• Oliver Brooks
CDC Co-Leads
• Lauri Markowitz
• Carla DeSisto
Work Group Members
• Pending
10
